Cervical cancer screening is a process using the Pap smear to identify precancerous and potentially precancerous changes in cervical cells and tissue. Cervical cancer acts as the biggest killer and most preventable cancer in Nepalese women. This paper tries to give a brief overview of cervical cancer screening program in Nepal. Various published and unpublished literatures were obtained and reviewed from international journals, local newspapers and books. All literatures were systematically reviewed and analyzed. Human papilloma virus (HPV) infection is chiefly the reason for cervical cancer. In majority cases, early exposure to sexual intercourse, multiple sex partners and addiction are considered as risk factor. In Developing country like Nepal, screening for cervical cancers is not easily available to people at risk. A vaccine is available which reduces the risk of HPV. The vaccine will be effective if received before the onset of sexual activities 9-13 years. Cervical cancer screening program has many difficulties in terms of limited medical services, difficult geographical terrain creating difficulties in delivering health services. Special programs needs to be designed and delivered to population focusing on reducing burden of cervical cancer. We are targeting poor women in this program.